Towards the development of natural product based anti-inflammatory therapy

نویسندگان

چکیده

Background: Jasminum grandiflorum is a medical plant widely used in Ayurvedic herbal medicines India. This host to very novel medicinal potential molecules such as iridoids. Flavonoids and other small are also elaborated by this plant. The present study was aimed understand the computational inhibition of phytochemicals against anti-inflammatory molecular targets. Methods: iridoids, flavonoids all were categorized subjected docking using Glide (Schrödinger Software suite) assess silico compounds with targets like COX1, COX2 Prostaglandin E synthase (mPGES-1). Results: Among tested compounds, iridoids namely 10-hydroxy- ligstroside 8-dehydroxy shanzhiside, flavonoid butin-7-O-β-D-glucopyranoside oleacein 2-(3,4-dihydroxyphenyl)ethanol predicted exhibit high properties due their low binding energy score. bioactive have good interaction targeted protein.

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Anti-Inflammatory Natural Products

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ژورنال

عنوان ژورنال: International Journal of Health Sciences (IJHS)

سال: 2022

ISSN: ['2550-6978', '2550-696X']

DOI: https://doi.org/10.53730/ijhs.v6ns6.10265